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Actos Heart Failure and Bladder Cancer

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 Actos (pioglitazone hydrochloride) is a member of a class of drugs known as thiazolidinediones, which have been linked to liver and cardiovascular issues. Actos side effects include increased risk of congestive heart failure (CHF), increased risk of rare but serious liver problems, an increased risk of fractures, and an increased risk for bladder cancer. The link between Actos and heart failure is strong enough that in 2007 the FDA increased the warnings on the drug concerning congestive heart failure. Actos is used to treat type 2 diabetes.

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Actos Bladder Cancer

 The FDA has issued a warning that Actos may be linked to an increased risk of bladder cancer, especially in patients who use the medication for more than one year. Information about the risk of bladder cancer will be added to the Actos warning label. Preliminary results from a long-term observational study found an increased risk of bladder cancer in patients with the longest exposure to Actos and the highest cumulative dose of the drug. Patients who have bladder cancer are urged not to use Actos, while the medication should be used with caution in patients who have a prior history of bladder cancer, the FDA warns.

Meanwhile, both Germany and France have suspended sales of Actos. The Actos suspension is effective July 11, 2011. Actos (pioglitazone), along with another diabetes drug made by Takeda Pharmaceutical, Competact, came under fire in Europe after a study revealed an increased risk for bladder cancer among diabetes patients who were taking the medication. The announcement of the suspension for Actos bladder cancer concerns may affect an estimated 230,000 individuals who currently use Actos or Competact in France alone, and those who have been prescribed Actos or Competact will now need to switch to another diabetes medication.

 Lawsuits have now reportedly been filed against Takeda Pharmaceuticals, alleging patients who took Actos developed bladder cancer. According to The Washington Post (08/05/11), the first of potentially thousands of lawsuits were filed in early August, alleging use of Actos was linked to the development of bladder cancer.

 Actos Rhabdomyolysis & Actos Kidney Failure

 The US Food and Drug Administration (FDA) has announced a potential safety issue with Actos (pioglitazone HCL) being linked to rhabdomyolysis. A potential safety issue means that the FDA has not established that there is a causal link between the two but that the drug is associated with the risk. FDA is evaluating the issue to determine if there is a need for regulatory action regarding Actos and rhabdomyolysis.

Rhabdomyolysis is a rare condition in which the muscle fibers deteriorate, resulting of the release of myoglobin into the blood flow. Rhabdomyolysis is characterized by muscle aches, pains and weakness. Rhabdomyolysis can result in kidney failure. The symptoms of rhabdomyolysis can include muscle weakness, fever, fatigue, pain or contracture, nausea, vomiting and dark colored urine. Because these symptoms can be easily confused with other ailments or conditions, it is important to report an onset of any such symptoms to your doctor.

Actos Heart Failure

Actos vs Avandia. A recent study funded by the Ontario Ministry of Health and Long Term Care and published on August 19, 2009, in the British Medical Journal has found that patients taking Actos have a lesser risk of developing heart failure or dying than patients taking rival drug Avandia. Researchers studied prescription data for nearly 40,000 patients age 66 and older who took Avandia or Actos between April 2002 and March 2008. However, despite the lessened risk, experts said patients with heart failure should avoid taking Actos. Actos has been linked to a risk of congestive heart failure.

While the study found Actos to present a lower potential risk of heart failure than Avandia, the study found no significant difference between Actos and Avandia when it came to a risk of heart attacks.

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